The chancellor and health secretary have resigned from government, saying they no longer have confidence in Boris Johnson to lead the country.
Chancellor Rishi Sunak said the public expected government to be conducted “properly, competently and seriously”.
Health Secretary Sajid Javid echoed this, saying the government was not “acting in the national interest”.
The resignations came minutes after the Prime Minister apologised for appointing Member of Parliament Chris Pincher to a government role.
Mr Johnson admitted he had made a “bad mistake” in appointing Mr Pincher to the role of deputy chief whip earlier this year, despite being told about earlier allegations about the MP’s conduct.
In an interview with newsmen, Mr Johnson said: “In hindsight it was the wrong thing to do. I apologise to everybody who has been badly affected by it.”
His handling of the row has faced fierce criticism from the opposition and some of his own MPs.
In a tweet, culture secretary and Mr Johnson loyalist Nadine Dorries said she was “100% behind the the PM who consistently gets all the big decisions right”.