Israeli forces raided the Al-Aqsa Mosque compound in occupied East Jerusalem with medics reporting at least 158 Palestinians injured in the ensuing violence as hundreds were detained.
The Islamic endowment that runs the site said Israeli police entered in force before dawn on Friday, as thousands of worshippers were gathered at the mosque for early morning prayers.
Videos circulating online showed Palestinians throwing rocks and police firing tear gas and stun grenades. Others showed worshippers barricading themselves inside the mosque amid what appeared to be clouds of tear gas.
It was the most serious violence at the holy site in nearly a year. Palestinians view any large deployment of police at Al-Aqsa as a provocation.
The Palestinian Red Crescent emergency service said it evacuated the majority of the wounded to hospitals.